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KEY TERMS activation lip 578 constitutive 574 cytokines 580 decoy receptors 606 erythropoietin 581 JAK-STAT pathway 581 kinase cascade 593 MAP kinase 593 NF-B pathway 601 NotchDelta pathway 601 nuclear-localization signal 576 PI-3 kinase pathway 598 presenilin 1 603 protein kinase B 599 PTEN phosphatase 600 Ras protein 587 receptor tyrosine kinases 578 regulated intramembrane proteolysis 603 scaffold proteins 597 SH2 domains 579 Smads 575 TGF superfamily 574 phosphoinositides 598 REVIEW THE CONCEPTS 1.

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