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Notably, germline deletion of CDKN2 exon lb sequences in a melanoma-astrocytoma syndrome family has been reported [170], which results in loss of ARF func- tion but not p 16 or p 15 and implicates ARF inactivation as a 8.

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Further activation takes place by binding of diacylglycerol to the C1 domain, which directly favors membrane association and enhances binding of phosphatidyl serine to the C2 domain, whereby these ligands serve as an anchor for membrane association.

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