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All rights reserved. Hofmann, G. 966 0. 36 The rotation angle of the rib cage around its intersection with the spine was defined as a piecewise linear function with respect to time, t, as shown in Equation 6.
) inflammatory second signals, Tradinv Ink4aARF locus, 237238 oncogene induced, models, 237240, 240f regulation by p53 and pRb, 236237, 236f replicative, 236237 Serpinopathies, 347t, 348 Serpins, metastable states, 357358 Sestrins, 161, 161f, 169 Shear stresses, 109110 physiological correlates, 111, 111t regions of low values, 110111, 111f shear stress responsive elements, 112 Sherrington, Arthur, 12 Short interfering RNAs (siRNAs), 260, 260f Signaling networks, Outside-in and inside-out maintains health, 179180, 180f roles of positive feedback, 449 See also Negative feedback; Positive feedback stabilizes disease states, 446448, 447f Sirtuins, 8687, 87t Sir2, 249, 249t SIRT1-mediated fatty acid oxidation, 8788, 88f Skeletal muscle fibers fast twitch, 167 fatty acid utilization, 166 metabolic programs, 166167 slow twitch, 167 Slicer, see Argonaute proteins Sliding clamp, MutS, 218 Slip bonds, 119121, 121f Small noncoding RNAs, 260 Smooth muscle cells, in the arterial wall, 108f SMRT, 79, 79t S-nitrosylation, 168170 feedback regulation of NOS enzymes, 170 NMDA receptors and excitotoxicity, 169 parkin, 169 Pdi, 169 SOCS3, negative regulation by, 38, 38f Somatostatin, Secretion by -cells, 21t Son of sevenless (Sos) proteins, 275, 277 Spinal and bulbar muscular atrophy (SBMA), 432t, 433 Spino-cerebellar ataxia 1, 432t, 433 Spino-cerebellar ataxia 3, 432433 Spongiform encephalopathies, see Prion diseases 26S proteasome, see Ubiquitin-proteasome system Src, see c-Src SREBPs cooperate with LXRs and FXRs, 97 family members, 9597 processing, RIP, 96, 96f Scap and Insig1, 96, 96f transcriptional targets, 9798 ssDNA-associated chromatin subcompartments (SDSCs), 203, 204f Stein, William, 348 Stellate cells, see Hepatic stellate cells Stem cells, 11 Stem cells, see Mesenchymal stem cells See also Cancer stem cells; Induced pluripotent stem (iPS) cells Stern, Otto, 8 Stroke volume, 164, 164f Stromal vascular fraction, 145 SUMO proteins, 143, 144f E1, E2 and E3 enzymes, 143 transrepression of TLR4 signaling, 144145, 144f Superoxide dismutase 1 (SOD1), 156157, 157f, 431432 mutations and aggregation, 441442 Nox regulation, 445446, 446f structure and function, 440, 441f Superoxide production, 156, 157158, 157f, 167 Sustained angiogenesis, in cancer, 181182, 181f Sutherland, E.
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